2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Potassium Channel

Potassium Channel

KcsA

Potassium Channel

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Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14848
    Naluzotan
    		Inhibitor 98.05%
    Naluzotan is a novel, potent, and selective amidosulfonamide 5-HT1A agonist with IC50 and Ki of appr 20 nM and 5.1 nM, used for the treatment of anxiety and depression; Also a weak hERG K+ channel blocker, with IC50 of 3800 nM.
    Naluzotan
  • HY-172182
    ONO-2920632
    		Activator 99.11%
    ONO-2920632 is an orally active and central nervous system (CNS)-penetrant TREK activator, with EC50 values of 0.3 µM and 2.8 μM for TREK-1 and TREK-2, respectively. ONO-2920632 exhibits selectivity for other K2P channels (>91-fold selective versus TASK1, TASK2, TASK3, TRAAK, and TWIK2; 31-fold selective versus TRESK). ONO-2920632 possesses analgesic effects and can be used in research on pain, migraine, and neurological disorders.
    ONO-2920632
  • HY-145992
    KCNQ1 activator-1
    		Activator 99.03%
    KCNQ1 activator-1 (compound 3) is a potent activator of KCNQ1 channel. KCNQ1 activator-1 has the potential for the research of long QT syndrome (LQTS).
    KCNQ1 activator-1
  • HY-P1427
    Guangxitoxin 1E
    		Inhibitor
    Guangxitoxin 1E is a potent and selective blocker of KV2.1 and KV2.2 channels. Guangxitoxin 1E inhibits KV2 with an IC50 of 1-3 nM. KV2 channels underlie delayed-rectifier potassium currents in various neurons.
    Guangxitoxin 1E
  • HY-131948
    3-Chlorodiphenylamine
    		Activator 98.74%
    3-Chlorodiphenylamine is a high affinity Ca2+ sensitizer of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of cardiac troponin C (cTnC) (Kd=6 µM). 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca2+-sensitizing compounds due to its small size, and can be used for systolic heart failure research.
    3-Chlorodiphenylamine
  • HY-161092A
    KIO-301 chloride hydrochloride
    		Inhibitor 99.61%
    KIO-301 chloride hydrochloride is an azobenzene photoswitchable compound that blocks voltage-gated ion channels, including hyperpolarization-activated cyclic nucleotide gating (HCN, during exposure to visible light) ) and voltage-gated potassium channels (voltage-gated potassium channels).
    KIO-301 chloride hydrochloride
  • HY-U00307
    Carabersat
    		Activator 98.22%
    Carabersat is a potent anticonvulsant agent.
    Carabersat
  • HY-P0249A
    Phe-Met-Arg-Phe amide trifluoroacetate
    		Activator 99.90%
    Phe-Met-Arg-Phe amide trifluoroacetate is an activator of K+ current, with ED50 of 23 nM in the peptidergic caudodorsal neurons.
    Phe-Met-Arg-Phe amide trifluoroacetate
  • HY-P2785
    Phrixotoxin-1
    		Inhibitor
    Phrixotoxin 1, from the venom of the theraphosid spider Phrixotrichus auratus, is a specific peptide inhibitor of Kv4 potassium channel.
    Phrixotoxin-1
  • HY-P5931
    Spinoxin
    		Inhibitor ≥98.0%
    Spinoxin isolated from the venom of scorpion Heterometrus spinifer, is a 34-residue peptide neurotoxin cross-linked by four disulfide bridges. Spinoxin is a potent inhibitor of Kv1.3 potassium channel (IC50 = 63 nM), considering to be valid molecular targets in the diagnostics and therapy of various autoimmune disorders and cancers.
    Spinoxin
  • HY-B1236
    Sulfacarbamide
    		99.25%
    Sulfacarbamide is a hypoglycemic active molecule that also acts on the plant nervous system.
    Sulfacarbamide
  • HY-B0267AS
    Oxybutynin-d11 chloride
    		Inhibitor
    Oxybutynin-d11 (chloride) is the deuterium labeled Oxybutynin chloride. Oxybutynin chloride is an anticholinergic agent, which inhibits vascular Kv channels in a concentration-dependent manner, with an IC50 of 11.51 μM.
    Oxybutynin-d<sub>11</sub> chloride
  • HY-134320
    8-Azido-ATP
    		Inhibitor
    8-Azido-ATP, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase. 8-Azido-ATP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    8-Azido-ATP
  • HY-N8404
    Chlorahololide C
    		Inhibitor ≥98.0%
    Chlorahololide C, a lindenane sesquiterpenoid dimer, is isolated from Chloranthus holostegius. Chlorahololide C is a potent and selective potassium channel blocker, with an IC50 of 3.6 μM.
    Chlorahololide C
  • HY-B0122R
    Topiramate (Standard)
    		Activator
    Topiramate (Standard) is the analytical standard of Topiramate. This product is intended for research and analytical applications. Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
    Topiramate (Standard)
  • HY-18172A
    (+)-KCC2 blocker 1
    		Inhibitor 98.68%
    (+)-KCC2 blocker 1 is a selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 0.4 μM. (+)-KCC2 blocker 1 is a benzyl prolinate and a enantiomer of KCC2 blocker 1.
    (+)-KCC2 blocker 1
  • HY-107301
    Dehydrosoyasaponin I
    		Activator 99.56%
    Dehydrosoyasaponin I (Soyasaponin Be;DHS-I), a triterpene glycoside, is a potent and reversible calcium-activated potassium (maxi-K) channels activator.
    Dehydrosoyasaponin I
  • HY-B1193R
    Terfenadine (Standard)
    		Inhibitor
    Terfenadine (Standard) is the analytical standard of Terfenadine. This product is intended for research and analytical applications. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.
    Terfenadine (Standard)
  • HY-B0563S
    (Rac)-Ropivacaine-d7
    		99.60%
    (Rac)-Ropivacaine-d7 is the deuterium labeled (Rac)-Ropivacaine.
    (Rac)-Ropivacaine-d<sub>7</sub>
  • HY-W014883
    1,12-Dodecanediamine
    		Inhibitor 99.44%
    1,12-Dodecanediamine (1,12-DD) is a reversible Maxi calcium-activated potassium channel blocker. 1,12-Dodecanediamine can reduce the single-channel current amplitude, mean channel open time, and channel open probability. 1,12-Dodecanediamine is promising for research of cell electrical signal transduction mechanism.
    1,12-Dodecanediamine
Cat. No. Product Name / Synonyms Application Reactivity